周艳;储丹丹;

• 1:南通大学医学院生化与分子生物学系
• 2:南通大学教育部/江苏省共建神经再生重点实验室/神经再生协同创新中心

摘要(Abstract)：

阿尔茨海默病(Alzheimer′s disease, AD)是一种常见的神经退行性疾病,目前尚缺乏有效的治疗和预防措施。AD的主要病理特征包括细胞外淀粉样斑块和细胞内神经元纤维缠结(neurofibrillary tangles, NFTs),后者主要由异常过度磷酸化的tau蛋白构成。NFT的积累程度与AD患者痴呆程度呈正相关。AD中tau病理的朊样聚集和传播可能是病程发展的关键驱动,针对tau病理的各类疗法不断涌现。本文对近年来AD中tau病理改变的研究进行综述,并简介基于tau病理的相应治疗策略。

关键词(KeyWords)： 阿尔茨海默病;tau病理;过度磷酸化;截断;聚集;传播

Abstract:

Keywords:

基金项目(Foundation): 南通市科技计划项目(JC2019098)

作者(Authors): 周艳;储丹丹;

DOI: 10.16424/j.cnki.cn32-1807/r.2021.03.012

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