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目的:分析2型糖尿病(type 2 diabetes,T2DM)患者并发骨质疏松症后骨密度(bone mineral density,BMD)的改变及其与各种危险因素的相关性,为早期诊断、早期防治糖尿病并发骨质疏松症提供理论依据。方法:根据受试者的骨密度值将糖尿病患者分为骨质疏松组(OP组)和非骨质疏松组(非OP组),对比两组T2DM患者的性别、年龄、体质量指数(body mass index,BMI)、糖尿病病程、空腹血糖(fasting blood glucose,FBG)、餐后2 h血糖(postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL)、三酰甘油(triglycerides,TG)、血清钙、磷、镁、碱性磷酸酶(alkaline phosphatase,ALP)和尿酸之间的差异,并进行相关性分析。结果:OP组与非OP组比较,年龄大、病程长、骨密度低、血磷高,两组间差异均有统计学意义(P<0.05)。T2DM患者的BMD与年龄、病程、ALP、HbA1c呈负相关,与BMI呈正相关;与空腹血糖、餐后2 h血糖、TG、LDL、血钙、血磷、血镁、尿酸无相关性。结论:高龄、低体质量、病程长、血糖控制差、高血ALP,都是糖尿病合并骨质疏松症的危险因素。
Abstract：Objective: To analyze the changes of bone mineral density(BMD) in type 2 diabetes(T2DM) patients and the correlation of risk factors,so as to provide arly diagnosis and prevention of diabetes complicated by osteoporosis.Methods: The patiants with T2DM was devided to osteoporosis group and non-osteoporosis group,accorrding to BMD values.Compare the following risk factors of two groups: sex,age,body mass index(BMI),duration of diabetes,fasting glucose,postprandial 2h blood glucose,glycosylated hemoglobin(HbA1c),low-density lipoprotein cholesterol(LDL),triglycerides,lipoprotein,serum calcium,phosphorus,magnesium,alkaline phosphatase(ALP) and uric acid,and analyze the correlation between the above risk factors with BMD in T2DM complicated by osteoporosis.Results: Fasting blood glucose(FBG),postprandial blood glucose(PBG),HbA1c was significantly increased.T2DM with BMD and age,disease duration,the ALP was negatively correlated,with BMI was positively correlated,with fasting blood glucose,2 h postprandial blood glucose,triglycerides,LDL,serum calcium,phosphorus,serum magnesium and uric acid was no correlation.Conclusion: The older age,low weight,long duration,poor blood glucose,high blood alkaline phosphatase were all the risk factors of diabetic patients with osteoporosis
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基本信息:
中图分类号:R587.1;R580
引用信息:
[1]孙兰芳,王玉洁,王友强,等.2型糖尿病合并骨质疏松症的危险因素分析[J].南通大学学报(医学版),2012,32(03):196-198.